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IL-6R / CD126 Neutralizing Antibody

IL-6R / CD126 Neutralizing Antibody

ArtNr	10398-MM08-200
Hersteller	Sino Biological
Menge	200 ug
Quantity options	200 ug 500 ug
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Antibodies By Cell Type Carcinoma Hematology Leukemia Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Primary Antibodies
Typ	Antibody Monoclonal
Clon	3H7D3H1
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	sino
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Manufacturer - Type	Antibody
Storage Conditions	This antibody can be stored at 2C-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Antigen molecule name	IL6R
Immunogen	Recombinant Human IL-6R / CD126 protein (Catalog#10398-H08H)
Purification	Protein A
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-6R / CD126 (rh IL-6R / CD126; Catalog#10398-H08H; NP_000556.1; Met1-Pro365). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Specificity	Human IL-6R / CD126
Buffer	0.2 um filtered solution in PBS (pH7.4) + 5% Trehalose Dihydrate
No cross-reactivity	No cross-reactivity with rat IL6R (81072-R02H), mouse IL6R (50280-M08H) and canine IL6R (70117-D08H) in ELISA assay
Block	This IL6R Neutralizing Antibody can not block the binding of recombinant IL6 (10395-HNAE) to its recombinant receptor IL6 Ralpha (10398-H08H).
Neutralization	The neutralization activity of IL6R Neutralizing Antibody is measured by its ability to neutralize IL6 Ralpha-mediated inhibition of proliferation in the M1 mouse myeloid leukemia cell line. The Neutralization Titer (IC50) is typically 0.15-0.6 ug/mL in the presence of 50 ng/mL Recombinant Human IL6 Ralpha (10398-H08H) and 100 ng/mL Recombinant Human IL6 (10395-HNAE).

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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10398-MM08-200-datasheet.pdf

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Menge: 200 ug

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