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Human TRAIL R2 / CD262 / TNFRSF10B Protein (His & Fc Tag)

Human TRAIL R2 / CD262 / TNFRSF10B Protein (His & Fc Tag)

ArtNr	10465-H03H-200
Hersteller	Sino Biological
Menge	200 ug
Quantity options	1 mg 100 ug 2 mg 200 ug 4 mg
Kategorie	Oncology By Cell Type Carcinoma Hematology Myeloma Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Apoptosis
Typ	Proteins
Specific against	Human (Homo sapiens)
Host	Human
Konjugat/Tag	HIS, Fc
Purity	> 95 % as determined by SDS-PAGE
Sequence	Met1-Glu182
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD262,DR5,KILLER,KILLER/DR5,TRAIL-R2,TRAILR2,TRICK2,TRICK2A,TRICK2B,TRICKB,ZTNFR9
Similar products	TNFRSF10B
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Manufacturer - Conjugate / Tag	C-human IgG1-Fc & His
Shipping Temperature	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Storage Conditions	Store it under sterile conditions at -20C to -80C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Antigen molecule name	TNFRSF10B
Protein Construction	A DNA sequence encoding the human TNFRSF10B (NP_003833.3) extracellular domain (Met 1-Glu 182) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Expressed Host	Human Cells
Bio-Activity	1. Measured by its binding ability in a functional ELISA. Immobilized human TNFSF10 at 10 ug/ml (100 ul/well) can bind human TNFRSF10B Fc chimera with a linear range of 2.5-40 ng/ml. 2. Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L?929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is typically 5-60 ng/ml in the presence of 20 ng/ml Recombinant Human TRAIL/TNFSF10.
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method
Predicted N Terminal	Ile 56
Molecule Mass	The recombinant human TNFRSF10B/Fc is a disulfide-linked homodimer. The reduced monomer consists of 375 amino acids and has a predicted molecular mass of 42.4 kDa. As a result of glycosylation, the apparent molecular mass of rh TNFRSF10B/Fc monomer migrates with an apparent molecular mass of 50 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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10465-H03H-200-datasheet.pdf

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Menge: 200 ug

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