Human beta-Catenin / CTNNB1 Protein (His & GST Tag)

A DNA sequence encoding the human CTNNB1 (P35222-1) (Met 1-Leu 781) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Measured by its ability to bind biotinylated mouse ERBB2 in a functional ELISA.

Met

Lyophilized from sterile 50mM Tris, 100mM NaCl, 2mM GSH, 10% gly, pH 8.0

Catenin beta-1, also known as CTNNB1, is a cytoplasm and nucleus protein which belongs to thebeta-catenin family. Catenin beta-1 / CTNNB1 contains 12ARM repeats. Catenin beta-1 / CTNNB1 is expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Catenin beta-1 / CTNNB1 is also expressed in colon. Catenin beta-1 / CTNNB1 is involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Catenin beta-1 / CTNNB1 is involved in signal transduction through the Wnt pathway. Nuclear beta-catenin is involved in transcriptional regulation by association with transcription factors of the TCF / LEF family. Defects in CTNNB1 are associated with colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB) susceptibility to ovarian cancer (OC).

P35222-1

N-GST & His

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

CTNNB1

CTNNB1

ambient

-20C

5% Mannitol, 5% Trehalose, 0.02% Tween80