Anti-CASP3 Antibody

Store at -20C. Avoid freeze / thaw cycles.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Affinity purification

Highly expressed in lung, spleen, heart, liver and kidney, Moderate levels in brain and skeletal muscle, and low in testis, Also found in many cell lines, highest expression in cells of the immune system

CASP3

For Research Use Only (RUO).