Hersteller |
St John's Laboratory
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human, Mouse |
Isotype |
IgG |
Applikationen |
WB, IF, IHC |
Menge |
100ul |
Host |
Rabbit |
ArtNr |
STJ115257-100 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P07108 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium-and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human DBI (NP_001171513. 1). |
Short Description |
Rabbit polyclonal against DBI |
Tissue specificity |
Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart. |
Cellular localization |
Endoplasmic ReticulumGolgi ApparatusGolgi Localization Is Dependent On Ligand Binding |
Molecular weight |
Calculated: 10kDa/11kDa/13kDa/14kDa/16kDa. Observed: 11kDa |
Dilution range |
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200 |
Alternative names |
Anti-Acyl-Coa-Binding Protein antibodyAnti-Acbp antibodyAnti-Diazepam-Binding Inhibitor antibodyAnti-Dbi antibodyAnti-Endozepine antibodyAnti-Ep antibodyAnti-DBI antibody |
Protein name |
Acyl-Coa-Binding ProteinAcbpDiazepam-Binding InhibitorDbiEndozepineEp |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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