Anti-UPF3B antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q9BZI7

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

UPF3B

Rabbit polyclonal against UPF3B

Nucleus
Cytoplasm
Shuttling Between The Nucleus And The Cytoplasm

WB 1:500-1:2000

Regulator Of Nonsense Transcripts 3b
Nonsense Mrna Reducing Factor 3b
Up-Frameshift Suppressor 3 Homolog B
Hupf3b
Up-Frameshift Suppressor 3 Homolog On Chromosome X
Hupf3p-X

REN3B_HUMAN