Manufacturer |
St John's Laboratory
|
Category |
|
Type |
Antibody Polyclonal |
Specific against |
Mouse |
Isotype |
IgG |
Applications |
WB |
Amount |
100ul |
Host |
Rabbit |
Item no. |
STJ117378-100 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q9BZI7 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human UPF3B (NP_075386. 1). |
Short Description |
Rabbit polyclonal against UPF3B |
Tissue specificity |
Expressed in testis, uterus, prostate, heart, muscle, brain, spinal cord and placenta. |
Cellular localization |
NucleusCytoplasmShuttling Between The Nucleus And The Cytoplasm |
Molecular weight |
Calculated: 56kDa/57kDa. Observed: 56kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Regulator Of Nonsense Transcripts 3b antibodyAnti-Nonsense Mrna Reducing Factor 3b antibodyAnti-Up-Frameshift Suppressor 3 Homolog B antibodyAnti-Hupf3b antibodyAnti-Up-Frameshift Suppressor 3 Homolog On Chromosome X antibodyAnti-Hupf3p-X antibodyAnti-UPF3B RENT3B UPF3X antibody |
Protein name |
Regulator Of Nonsense Transcripts 3bNonsense Mrna Reducing Factor 3bUp-Frameshift Suppressor 3 Homolog BHupf3bUp-Frameshift Suppressor 3 Homolog On Chromosome XHupf3p-X |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.