RS 102895 Hydrochloride (1’-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4’-piperidin]-2(1H)-one Hydrochloride, RS 102895, RS102895)

Blue Ice

426, 86

Supplied as an off-white powder.

A selective antagonist for CCR2 receptors (IC50 = 0.36 and 17.8uM for CCR2b and CCR1 receptors, respectively). Blocks monocyte chemoattractant protein-1 induced calcium influx and chemotaxis (IC50 = 32nM and 1.7uM respectively). A potential anti-inflammatory therapeutic agent by Inhibiting alpha1A, alpha1D and 5-HT1A receptors.

Synonyms: 1ʹ-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3, 1-benzoxazine-4, 4ʹ-piperidin]-2(1H)-one hydrochloride, RS 102895, RS102895

CAS Number:
300815-41-2

Formula:
C21H21F3N2O2•HCl

Solubility:
DMSO

Appearance:
Supplied as an off-white powder.

Primary Target:
CCR2

Primary Target IC50:
0.36 and 17.8uM for human recombinant CCR2b and CCR1 receptors, respectively.

Molecular Weight:
426.86

Storage and Stability:
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.