OGG1 Antibody

OGG1 Antibody is a Rabbit Polyclonal antibody against OGG1. This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.

Image Legend: Fig. 1. Western blot analysis of extracts of various cell lines, using OGG1 antibody(1:200).

Unconjugated

Affinity purified.

O15527

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

This product is for research use only.