Comparison

Human IFN-beta protein

Item no. ABK-PRP100183-100ug
Manufacturer Abbkine Scientific
Amount 100ug
Category
Type Proteins
Specific against other
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Available
Sequence
Amino acid sequence derived from human IFNbeta (P01574) (Met1-Asn187) was expressed.
Activity
Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitisvirus (VSV).
The EC50 for this effect is 1-5 pg/mL.
Protein length
The recombinant human IFNbeta consists of 166 amino acids and predicts a molecular mass of 20 KDa. It migrates as an approximately 20-23 KDa band in SDS-PAGE under reducing conditions.
Preparation method
CHO Stable Cells
Purity
> 95 % as determined by SDS-PAGE
Formulation
Lyophilized from sterile 50mM Hepes, pH 7.0
Molecular weight
20 kDa
Usage notes
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IFN-beta protein in sterile ddH2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Storage instructions
Lyophilized Human IFN-beta protein product should be stored desiccated below -18C. Upon reconstitution, the protein should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Shipping
The product is shipped at ambient temperature.
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Background
Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites and tumor cells. Interferon-beta (IFN beta) is an extra-cellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis. The recombinant IFN beta protein has the theoretical potential to either treat or cause autoimmune neuromuscular disorders by altering the complicated and delicate balances within the immune system networks. It is the most widely prescribed disease-modifying therapy for multiple sclerosis (MS). Large-scale clinical trials have established the clinical efficacy of IFN beta in reducing relapses and slowing disease progression in relapsing-remitting MS. IFN beta therapy was shown to be comparably beneficial for opticospinal MS (OSMS) and conventional MS in Japanese. IFN beta is effective in reducing relapses in secondary progressive MS and may have a modest effect in slowing disability progression. In addition to the common antiviral activity, IFN beta also induces increased production of the p53 gene product which promotes apoptosis, and thus has therapeutic effect against certain cancers. The role of IFN-beta in bone metabolism could warrant its systematic evaluation as a potential adjunct to therapeutic regimens of osteolytic diseases. Furthermore, IFN beta might play a beneficial role in the development of a chronic progressive CNS inflammation.
Gene ID
3456
Alternative
IFB; IFF; IFN-beta; IFNB; Interferon beta; Interferon beta; IFNB1
Other info
The Endotoxin level is less than 1.0 EU per ug of the protein as determined by the LAL method
Accession
P01574

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100ug
Available: In stock
available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close