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Anti-CD59 (glycoprotein) Antibody

Anti-CD59 (glycoprotein) Antibody

Item no.	ABC-AN1699
Manufacturer	Abcepta
Amount	100 ul
Category	Neuroscience Neuroinflammation Antibodies Immunohistochemistry Western Blot
Type	Antibody Monoclonal
Applications	WB, IHC
Clone	M015
Specific against	other
Host	Mouse
Isotype	IgG2b
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CD59 glycoprotein,1F5 antigen,HRF-20,HRF20,MAP-IP,MAC inhibitory protein,MEM43,MACIF,MIRL,MIC11,MIN1,MIN2,MIN3,MSK21
Available
Manufacturer - Category	Primary Antibodies; Antibody Collections; Cardiovascular; Immunology; Signal Transduction; Stem Cells; Head neck negative; Cervix negative; Pancreas negative; Stomach negative
Manufacturer - Targets	CD59 is a GPI-anchored membrane protein that is an inhibitor of the complement membrane attack complex (MAC). CD59 binds to complement components C8 and C9, preventing C9 polymerization and insertion into membranes. Rare cases of CD59 deficiency have been reported to cause paroxysmal nocturnal hemoglobinuria in human patients. Expression of CD59 on tumor cells and viral infected cells makes them resist antibody-dependent complement-mediated lysis. Inhibitors of CD59 expression or activity may suppress tumor cell resistance to complement-mediated attack, and these technologies have been actively pursued for therapeutic applications. In addition, CD59 may regulate insulin secretion by modulating exocytosis, and a glycated form of CD59 with no MAC inhibitory activity is found in diabetic patients.
Bio Background	CD59 is a GPI-anchored membrane protein that is an inhibitor of the complement membrane attack complex (MAC). CD59 binds to complement components C8 and C9, preventing C9 polymerization and insertion into membranes. Rare cases of CD59 deficiency have been reported to cause paroxysmal nocturnal hemoglobinuria in human patients. Expression of CD59 on tumor cells and viral infected cells makes them resist antibody-dependent complement-mediated lysis. Inhibitors of CD59 expression or activity may suppress tumor cell resistance to complement-mediated attack, and these technologies have been actively pursued for therapeutic applications. In addition, CD59 may regulate insulin secretion by modulating exocytosis, and a glycated form of CD59 with no MAC inhibitory activity is found in diabetic patients.
Clonality	Mouse Monoclonal
Gene Name	CD59
Calculated Molecular Weight	14177
Formulation	Protein G Purified

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 11/6/2025

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