« Back
Home /
BMS-599626

BMS-599626

Item no.	M1684-50mg
Manufacturer	AbMole
CASRN	8173837-23-1
Amount	50mg
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Specific against	other
Purity	>99%
Citations	Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors. Soria, et al . Ann Oncol. 2012 Feb,23(2):463-71. PMID: 21576284 . AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Torres, et al . Invest New Drugs. 2011 Aug,29(4):554-61. PMID: 20119866 . Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases. Gavai, et al . J Med Chem. 2009 Nov 12,52(21):6527-30. PMID: 19821562 . Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Wong, et al . Clin Cancer Res. 2006 Oct 15,12(20 Pt 1):6186-93. PMID: 17062696 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AC480
Similar products	BMS-599626, AC480
Available
Molecular Weight	567, 01
Solubility	DMSO
Bioactivity information	BMS-599626 (AC480) is an orally bioavailable pan-HER tyrosine kinase inhibitor with potential antineoplastic activity.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

M1684-50mg-safety-datasheet.pdf