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GDC-0879

GDC-0879

Item no.	M1714-200mg
Manufacturer	AbMole
CASRN	905281-76-7
Amount	200mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer
Type	Inhibitors
Specific against	other
Purity	0,9968
Citations	Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0879 and its metabolite in dog plasma using solid phase extraction. Chou, et al . J Pharm Biomed Anal. 2012 Nov,70:354-61. PMID: 22717139 . Disposition of GDC-0879, a B-RAF kinase inhibitor in preclinical species. Choo, et al . Xenobiotica. 2009 Sep,39(9):700-9. PMID: 19552528 . Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression. Hoeflich, et al . Cancer Res. 2009 Apr 1,69(7):3042-51. PMID: 19276360 . Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy. Wong, et al . J Pharmacol Exp Ther. 2009 Apr,329(1):360-7. PMID: 19147858 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Similar products	GDC-0879
Available
Target Information	Raf
Molecular Weight	334, 37
Solubility	DMSO 47 mg/mL
Bioactivity information	GDC-0879 is a potent and selective B-Raf kinase inhibitor with an EC50 of 0.75 µM.

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M1714-200mg-safety-datasheet.pdf