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GDC-0941 (Pictilisib)

GDC-0941 (Pictilisib)

Item no.	M1715-10mg
Manufacturer	AbMole
CASRN	957054-30-7
Amount	10mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	>99%
Citations	Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice. Nishida, et al . Hypertension. 2012 Oct,60(4):981-90. PMID: 22949526 . Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels. Bressanin, et al . Oncotarget. 2012 Aug,3(8):811-23. PMID: 22885370 . Design, Synthesis and Anticancer Activity of 4-Morpholinothieno[3,2- d ]pyrimidine Derivatives Bearing Arylmethylene Hydrazine Moiety. Zhu, et al . Chem Pharm Bull (Tokyo). 2012,60(8):1037-45. PMID: 22863708 . GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of docetaxel in human breast cancer models by increasing cell death in vitro and in vivo. Wallin, et al . Clin Cancer Res. 2012 Jul 15,18(14):3901-11. PMID: 22586300 . ErbB3 inhibitory surrobodies inhibit tumor cell proliferation in vitro and in vivo. Foreman, et al . Mol Cancer Ther. 2012 Jul,11(7):1411-20. PMID: 22553357 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Pictilisib
Similar products	GDC-0941
Available
Molecular Weight	513, 64
Solubility	DMSO 40 mg/mL
Bioactivity information	GDC-0941 is a selective and potent inhibitor of Class I PI3K, p110a IC50=0.003uM, U87MG IC50=0.95μM.

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M1715-10mg-safety-datasheet.pdf