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MLN8237 (Alisertib)

MLN8237 (Alisertib)

Item no.	M1752-200mg
Manufacturer	AbMole
CASRN	1028486-01-2
Amount	200mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Specific against	other
Purity	0,9917
Citations	Pediatric Phase 1 Trial and Pharmacokinetic Study of MLN8237, an Investigational Oral Selective Small Molecule Inhibitor of Aurora Kinase A: A Children's Oncology Group Phase 1 Consortium study. Mosse YP, et al . Clin Cancer Res. 2012 Sep 17. PMID: 22988055 . Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. Matulonis UA, et al . Gynecol Oncol. 2012 Oct,127(1):63-9. PMID: 22772063 . Phase I Study of Aurora A Kinase Inhibitor MLN8237 in Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics, and Bioavailability of Two Oral Formulations. Dees EC, et al . Clin Cancer Res. 2012 Sep 11,18(17):4775-84. PMID: 22767670 . Phase I Pharmacokinetic/Pharmacodynamic Study of MLN8237, an Investigational, Oral, Selective Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors. Cervantes A, et al . Clin Cancer Res. 2012 Sep 1,18(17):4764-74. PMID: 22753585 . Additive effects of vorinostat and MLN8237 in pediatric leukemia, medulloblastoma, and neuroblastoma cell lines. Muscal JA, et al . Invest New Drugs. 2012 Jun 6. PMID: 22669335 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Alisertib
Similar products	MLN8237, Alisertib
Available
Target Information	Aurora Kinase
Molecular Weight	518, 92
Solubility	DMSO 26 mg/mL
Bioactivity information	MLN8237 (Alisertib) is a second-generation, orally bioavailable, highly selective Aurora kinase A inhibitor with IC50 of 61 nM.

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M1752-200mg-safety-datasheet.pdf