WP1130

Item no.	M1754-200mg
Manufacturer	AbMole
CASRN	856243-80-6
Amount	200mg
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	0,9894
Citations	Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response. Perry JW, et al . PLoS Pathog. 2012 Jul,8(7):e1002783. PMID: 22792064 . A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination. Kapuria V, et al . Cell Signal. 2011 Dec,23(12):2076-85. PMID: 21855629 . Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis. Kapuria V, et al . Cancer Res. 2010 Nov 15,70(22):9265-76. PMID: 21045142 . Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells. Bartholomeusz GA, et al . Blood. 2007 Apr 15,109(8):3470-8. PMID: 17202319 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Degrasyn
Similar products	WP1130
Available
Target Information	JAK
Molecular Weight	384, 3
Solubility	DMSO 60 mg/mL
Bioactivity information	Degrasyn (WP1130) is a small molecular deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway.

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M1754-200mg-safety-datasheet.pdf