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Foretinib

Foretinib

Item no.	M1758-200mg
Manufacturer	AbMole
CASRN	849217-64-7
Amount	200mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Gastric Cancer Hepatic Cancer
Type	Inhibitors
Specific against	other
Purity	0,9943
Citations	Phase II trial of single-agent foretinib (GSK1363089) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. Seiwert T, et al . Invest New Drugs. 2012 Aug 24. PMID: 22918720 . Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma. Huynh H, et al . Angiogenesis. 2012 Mar,15(1):59-70. PMID: 22187171 . Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks. Kataoka Y, et al . Invest New Drugs. 2012 Aug,30(4):1352-60. PMID: 21655918 . Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis. Zillhardt M, et al . Clin Cancer Res. 2011 Jun 15,17(12):4042-51. PMID: 21551255 . Synergistic effects of foretinib with HER-targeted agents in MET and HER1- or HER2-coactivated tumor cells. Liu L, et al . Mol Cancer Ther. 2011 Mar,10(3):518-30. PMID: 21252284 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	XL880, GSK1363089
Similar products	Foretinib, XL880, GSK1363089
Available
Molecular Weight	632, 65
Solubility	DMSO 90 mg/mL
Bioactivity information	Foretinib (XL880, GSK1363089) is a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2 (VEGFR2) with IC50 value of 0.4 nM for c-MET.

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M1758-200mg-safety-datasheet.pdf