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Palomid 529

Palomid 529

Item no.	M1760-200mg
Manufacturer	AbMole
CASRN	914913-88-5
Amount	200mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Purity	1
Citations	High-performance liquid chromatography analysis of a novel small-molecule, anti-cancer drug, Palomid 529, in human and mouse plasma and in mouse tissue homogenates. Lin F, et al . J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Dec 15,879(32):3823-31. PMID: 22100549 . The TORC1/TORC2 inhibitor, Palomid 529, reduces tumor growth and sensitizes to docetaxel and cisplatin in aggressive and hormone-refractory prostate cancer cells. Gravina GL, et al . Endocr Relat Cancer. 2011 Jul 1,18(4):385-400. PMID: 21551258 . The novel Akt inhibitor Palomid 529 (P529) enhances the effect of radiotherapy in prostate cancer. Diaz R, et al . Br J Cancer. 2009 Mar 24,100(6):932-40. PMID: 19240717 . Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability. Xue Q, et al . Cancer Res. 2008 Nov 15,68(22):9551-7. PMID: 19010932 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	P529
Similar products	Palomid 529, P529
Available
Molecular Weight	406, 43
Solubility	DMSO 30 mg/mL
Bioactivity information	Palomid 529 (P529) is a novel potent PI3K/Akt/mTOR inhibitor and shows a potent antiproliferative activity in the NCI-60 cell lines panel, with growth inhibitory 50 (GI50) <35 μM.

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M1760-200mg-safety-datasheet.pdf