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SB431542

SB431542

Item no.	M1794-200mg
Manufacturer	AbMole
CASRN	301836-41-9
Amount	200mg
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Bone Cancer Neurodegeneration Markers
Type	Inhibitors
Specific against	other
Purity	0,9983
Citations	Differential signalling through ALK-1 and ALK-5 regulates leptin expression in mesenchymal stem cells. Zeddou M, et al . Stem Cells Dev. 2012 Jul 20,21(11):1948-55. PMID: 22087763 . Activation of the activin A-ALK-Smad pathway in systemic sclerosis. Takagi K, et al . J Autoimmun. 2011 May,36(3-4):181-8. PMID: 21377836 . Transforming growth factor beta1 down-regulates Runx-2 and alkaline phosphatase activity of human dental pulp cells via ALK5/Smad2/3 signaling. Lin PS, et al . Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Mar,111(3):394-400. PMID: 21236710 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SB-431542
Similar products	SB431542, SB-431542
Available
Molecular Weight	384, 39
Solubility	DMSO 40 mg/mL
Bioactivity information	SB-431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM).

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M1794-200mg-safety-datasheet.pdf