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PD 0332991 HCL

PD 0332991 HCL

Item no.	M1806-200mg
Manufacturer	AbMole
CASRN	827022-32-2
Amount	200mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer
Type	Inhibitors
Specific against	other
Purity	0,999
Citations	Cdk4/6 Inhibition Induces Epithelial-Mesenchymal Transition and Enhances Invasiveness in Pancreatic Cancer Cells. Liu F, et al . Mol Cancer Ther. 2012 Aug 6. PMID: 22869556 . Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors. Dean JL, et al . Cell Cycle. 2012 Jul 15,11(14):2756-61. PMID: 22767154 . Phase I, dose-escalation trial of the oral cyclin-dependent kinase 4/6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer. Flaherty KT, et al . Clin Cancer Res. 2012 Jan 15,18(2):568-76. PMID: 22090362 . Quantitative analysis of PD 0332991 in mouse plasma using automated micro-sample processing and microbore liquid chromatography coupled with tandem mass spectrometry. Smith D, et al . J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Oct 1,879(27):2860-5. PMID: 21889427 . Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression. Katsumi Y, et al . Biochem Biophys Res Commun. 2011 Sep 16,413(1):62-8. PMID: 21871868 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Palbociclib HCl
Similar products	PD 0332991, PD0332991, Palbociclib
Available
Target Information	CDK
Molecular Weight	483, 99
Solubility	DMSO 4 mg/mL warmed; Water 30 mg/mL
Bioactivity information	PD-0332991 HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc.

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M1806-200mg-safety-datasheet.pdf