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PD98059

PD98059

Item no.	M1822-1g
Manufacturer	AbMole
CASRN	167869-21-8
Amount	1g
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	0,9983
Citations	PD98059 and U0126 activate AMP-activated protein kinase by increasing the cellular AMP:ATP ratio and not via inhibition of the MAP kinase pathway. Dokladda K, et al . FEBS Lett. 2005 Jan 3,579(1):236-40. PMID: 15620719 . Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha. Hur E, et al . Mol Pharmacol. 2001 May,59(5):1216-24. PMID: 11306706 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PD 98059
Similar products	PD98059, PD 98059
Available
Target Information	MEK
Molecular Weight	267, 28
Solubility	DMSO 15 mg/mL
Bioactivity information	PD98059 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MKK / MEK) with IC50 value of 2-7 μM. The expression of KAT2B protein in cells is significantly decreased after PD98059 inhibits ERK signaling pathway.

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M1822-1g-safety-datasheet.pdf