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MK-2206 2HCl

MK-2206 2HCl

Item no.	M1837-200mg
Manufacturer	AbMole
CASRN	1032350-13-2
Amount	200mg
Category	Oncology Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Specific against	other
Purity	0,9918
Citations	Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice. Nishida, et al . Hypertension. 2012 Sep 4. PMID: 22949526 . Biomarkers of Response to Akt Inhibitor MK-2206 in Breast Cancer. Sangai, et al . Clin Cancer Res. 2012 Aug 29. PMID: 22932669 . Inhibition of AKT with the Orally Active Allosteric AKT Inhibitor, MK-2206, Sensitizes Endometrial Cancer Cells to Progestin. Pant, et al . PLoS One. 2012,7(7):e41593. PMID: 22911820 . Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels. Bressanin, et al . Oncotarget. 2012 Aug 9. PMID: 22885370 . A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle. Lai, et al . Biochem J. 2012 Jul 13. PMID: 22793019 . Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia. Simioni, et al . Leukemia. 2012 May 22. PMID: 22614243 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MK-2206 dihydrochloride
Similar products	MK-2206, MK-2206 2HCl
Available
Target Information	Akt
Molecular Weight	480, 39
Solubility	DMSO 12 mg/mL
Bioactivity information	MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively.

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M1837-200mg-safety-datasheet.pdf