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Dacomitinib

Dacomitinib

Item no.	M1869-200mg
Manufacturer	AbMole
CASRN	1110813-31-4
Amount	200mg
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Breast Cancer
Type	Inhibitors
Specific against	other
Purity	0,9974
Citations	Dacomitinib (PF-00299804), an Irreversible Pan-HER Inhibitor, Inhibits Proliferation of HER2-Amplified Breast Cancer Cell Lines Resistant to Trastuzumab and Lapatinib. Kalous, et al . Mol Cancer Ther. 2012 Sep,11(9):1978-87. PMID: 22761403 . Randomized Phase II Study of Dacomitinib (PF-00299804), an Irreversible Pan-Human Epidermal Growth Factor Receptor Inhibitor, Versus Erlotinib in Patients With Advanced Non-Small-Cell Lung Cancer. Ramalingam, et al . J Clin Oncol. 2012 Jul 2. PMID: 22753918 . Phase I and pharmacokinetic study of dacomitinib (PF-00299804), an oral irreversible, small molecule inhibitor of human epidermal growth factor receptor-1, -2, and -4 tyrosine kinases, in Japanese patients with advanced solid tumors. Takahashi, et al . Invest New Drugs. 2012 Jan 17. PMID: 22249430 . The effect of dacomitinib (PF-00299804) on CYP2D6 activity in healthy volunteers who are extensive or intermediate metabolizers. Bello, et al . Cancer Chemother Pharmacol. 2012 Apr,69(4):991-7. PMID: 22147075 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PF-00299804
Similar products	Dacomitinib, PF-00299804
Available
Molecular Weight	469, 94
Solubility	DMSO ≥ 25 mg/mL
Bioactivity information	Dacomitinib (PF-00299804) is an oral, irreversible, small molecule inhibitor of human epidermal growth factor receptor-1, -2, and -4 tyrosine kinases.

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M1869-200mg-safety-datasheet.pdf