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LY2886721

LY2886721

Item no.	M1987-10mg
Manufacturer	AbMole
CASRN	1262036-50-9
Amount	10mg
Category	Neuroscience Protein Aggregation, Clearance & Misfolding Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	>99.0%
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Similar products	LY2886721
Available
Target Information	BACE
Molecular Weight	390, 41
Solubility	DMSO
Bioactivity information	LY2886721 is an effective, selective, orally active inhibitor of beta-site amyloid precursor protein lyase 1 (BACE1) with an IC50 of 20.3 nM against recombinant human BACE1. LY2886721 showed higher selectivity for BACE1 than cathepsin D, pepsin and renin, but lacked selectivity for BACE2 (IC50 was 10.2 nM). LY2886721 crosses the blood-brain barrier and can be used to study Alzheimer's disease.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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M1987-10mg-safety-datasheet.pdf