SC144

Item no.	M3001-100mg
Manufacturer	AbMole
CASRN	895158-95-9
Amount	100mg
Category	Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,9986
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Target Information	IL Receptor/Related
Molecular Weight	322, 3
Solubility	DMSO 15 mg/mL
Bioactivity information	SC144 is the first oral active GP130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, eliminates Stat3 phosphorylation and nuclear translocation, and further inhibits downstream target gene expression. SC144 inhibited signal transduction induced by GP130 ligand. SC144 induces apoptosis of human ovarian cancer cells.

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M3001-100mg-safety-datasheet.pdf