E7449

Item no.	M5267-25mg
Manufacturer	AbMole
CASRN	1140964-99-3
Amount	25mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer
Type	Inhibitors
Specific against	other
Purity	>98%
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Stenoparib; 2X-121; MGI25036
Available
Target Information	PARP
Molecular Weight	317, 34
Solubility	4 mg/mL in DMSO
Bioactivity information	E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.

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M5267-25mg-safety-datasheet.pdf