SensoLyte® Anti-PLP (178-191) IgG Quantitative ELISA Kit (mouse) Colorimetric - 1 kit

Myelin Proteolipid Protein (PLP)

Store all other components at 4°C for up to 6 months. Store component B at -20°C in small aliquots. Protect components E and G from light.

Proteolipid protein (PLP) is the most abundant protein in the central nervous system (CNS) myelin sheath and is highly conserved among species. PLP has a 50% hydrophobic amino acids content and a molecular weight of 30 kDa. Mouse PLP (178-191) is able to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination. Autoantibody response to mouse PLP (171-191) has been observed in induced experimental autoimmune encephalomyelitis (EAE) in B10.PL, SJL, C57BL/6, F1, and BALB/c mice strains. However, the exact pathological role and action of anti-mouse PLP (178-191) autoantibody is not well understood.
The SensoLyte® Anti-PLP (178-191) IgG Quantitative ELISA Kit (mouse) provides a convenient and quantitative assay for anti-PLP (178-191) autoantibody in mouse. This kit is useful to researchers who want to determinine the amount of anti-PLP (178-191) antibody present in biological samples, and can help provide information on the role it plays in the development and treatment of EAE, an animal model for MS pathogenesis.

Colorimetric

mouse

Research use

5400535008185