[Leu27]-Melan-A, MART-1 (26-35)

Catalog Peptides / Catalog Peptides Gr / Peptides

RT

985.3

This Melan-A (26-35) analog, Leu substituted for Ala at position 27, shows better HLA-A*0201 binding properties as well as better immunogenicity and antigenicity than the natural Melan-A (26-35). - Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic ?-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

One unit of protease hydrolyzes 1 picomole of 5-FAM/QXL™ FRET substrate per minute at pH 7.5 at 25°C.

Research use

5400535155711