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Fibrinogen gamma-Chain (377-395) - 1 mg

Fibrinogen gamma-Chain (377-395) - 1 mg

Item no.	AS-62128
Manufacturer	AnaSpec
Amount	1 mg
Category	Peptides & Proteins Cell Biology Cell Movement Cell Adhesion Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Conjugate/Tag	Unconjugated
Purity	Peak Area by HPLC ≥95%
Sequence	H-Tyr-Ser-Met-Lys-Glu-Thr-Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Ser-Ile-Gly-OH
Citations	Adams, R. et al. J. Exp. Med. Published online 5 March 2007 doi:10.1084/jem.20061931
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	YSMKETTMKIIPFNRLSIG
Shipping Condition	Room temperature
Available
Manufacturer - Type	Catalog
Manufacturer - Category	Peptides
Manufacturer - Targets	Fibrinogen
Shipping Temperature	RT
Storage Conditions	- 20 °C
Molecular Weight	2229.8
Description	This fibrinogen-derived inhibitory peptide attenuates microglia activation and suppresses relapsing paralysis in multiple sclerosis (MS). Fibrinogen is a regulator of microglia activation and interaction of fibrinogen with the microglia integrin receptor Mac-1. Because blocking fibrinogen-Mac-1 interactions affects the pro-inflammatory but not the pro-coagulant properties of fibrinogen, targeting this gamma- fibrinogen epitope could represent a potential therapeutic strategy for MS and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation.
Product Group	LB1A1Z
Research Area	Cardiovascular Research / Lyophilized
Sequence One-Letter Code	YSMKETTMKIIPFNRLSIG
GTIN	5400535149819
Usage	Research use
UNSPSC	12352202

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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AS-62128-safety-datasheet.pdf