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Protease-Activated Receptor-1, PAR-1 Agonist 1, amide

Protease-Activated Receptor-1, PAR-1 Agonist 1, amide

Item no.	AS-62937
Manufacturer	AnaSpec
Amount	5 mg
Category	Neuroscience Molecular Targets for Neuroscience Peptides & Proteins Cardiovascular Research Thrombosis & Hemostasis Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Conjugate/Tag	Unconjugated
Purity	Peak Area by HPLC ≥95%
Sequence	H-Thr-Phe-Leu-Leu-Arg-Asn-NH2
Citations	1, Kauffmann, R. et al. Oncol. Rep. 21:1261-1267 (2009). 2, Kirilak, YA. et al. Intl. J. Mol. Med. 17:551-558 (2006).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	TFLLRN-NH2
Shipping Condition	Room temperature
Available
Manufacturer - Category	Catalog Peptides / Catalog Peptides Gr / Peptides
Manufacturer - Targets	Protease-Activated Receptor (PAR)
Shipping Temperature	RT
Storage Conditions	- 20 °C
Molecular Weight	761.9
Manufacturer - Research Area	Cardiovascular Research; Cell Signaling / Coagulation; GPCR
Description	Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.
Sequence One-Letter Code	TFLLRN-NH2
Post Synthesis Coupling	No
Usage	Research use
UNSPSC	12352202
GTIN	5400535147877

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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AS-62937-safety-datasheet.pdf