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Kisspeptin-10 (Kp-10) (112-121), Metastin (45-54), human

Kisspeptin-10 (Kp-10) (112-121), Metastin (45-54), human

Item no.	AS-64240
Manufacturer	AnaSpec
CASRN	374675-21-5
Amount	1 mg
Category	Peptides & Proteins Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Conjugate/Tag	Unconjugated
Purity	Peak Area by HPLC ≥95%
Sequence	H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Citations	Kadokawa, H. et al. J. Endocrinol. 196, 331 (2008); Kotani, M. et al. J. Biol. Chem. 276, 34631 (2001); Navenot, J.M. et al. Cancer Res, 65, 10450 (2005).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	YNWNSFGLRF-NH2
Shipping Condition	Room temperature
Available
Manufacturer - Category	Catalog Peptides / Catalog Peptides Gr / Peptides
Manufacturer - Targets	Kisspeptin
Shipping Temperature	RT
Storage Conditions	- 20 °C
Molecular Weight	1302.5
Manufacturer - Research Area	Hormones; Cell Signaling; Cancer & Apoptosis; Neuroscience / Hypothalamo-Pituitary (HPA) Axis; GPCR; Oncogenesis; Neuropeptides
Description	Kisspeptin was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis. Kisspeptin-GPR54 signaling has an important role in initiating secretion of gonadotropin-releasing hormone (GnRH) at puberty from the anterior pituitary. This peptide sequence is found in residues 45 to 54 of Metastin (also referred to as Kisspeptin-10). This peptide increases plasma concentrations of GH (Growth Hormone) and LH (Luteinizing Hormone) in prepubertal dairy heifers. This peptide is the minimal sequence needed to activate GPR54 signaling, which may function in negatively regulating CXCR4’s role in programming tumor metastasis. Specifically, Kisspeptin-10 inhibits signaling and chemotaxis induced by SDF-1.
Sequence One-Letter Code	YNWNSFGLRF-NH2
Post Synthesis Coupling	No
Usage	Research use
UNSPSC	12352202
GTIN	5400535145323

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AS-64240-safety-datasheet.pdf