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Endothelin 1, human, HiLyte™ Fluor 488-labeled

Endothelin 1, human, HiLyte™ Fluor 488-labeled

Item no.	AS-64817-025
Manufacturer	AnaSpec
Amount	0.25 mg
Category	Peptides & Proteins Cardiovascular Research Hypertension Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Purity	Peak Area by HPLC ≥95%
Sequence	Hilyte™ Fluor 488-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide Bridge: 1-15 and 3-11)
Citations	Yanagisawa, M. et al. Nature 332, 411 (1988).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	HiLyte Fluor 488-CSCSSLMDKECVYFCHLDIIW (Disulfide Bridge: 1-15 and 3-11)
Shipping Condition	Room temperature
Available
Manufacturer - Category	Catalog Peptides / Catalog Peptides Gr / Peptides
Manufacturer - Targets	Endothelin
Manufacturer - Conjugate / Tag	Fluorescent dyes: HiLyte™ Fluor 488
Shipping Temperature	RT
Storage Conditions	- 20 °C Protected from light
Molecular Weight	2848.4
Manufacturer - Research Area	Cardiovascular Research; Cell Signaling / Vasoconstriction/Vasodilation; GPCR
Description	This is a fluorescent (HiLyte™ Fluor 488)-labeled Endothelin 1 (ET-1) peptide, Abs/Em=503/528 nm. ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.
Absorbtion (nm)	503
Emission (nm)	528
Sequence One-Letter Code	HiLyte™ Fluor 488-CSCSSLMDKECVYFCHLDIIW (Disulfide Bridge: 1-15 and 3-11)
Detection Method	Fluorescent
Post Synthesis Coupling	No
Usage	Research use
UNSPSC	12352202
GTIN	5400535142575

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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AS-64817-025-safety-datasheet.pdf