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[Lys(Ac)12/16, Lys(Me3)20]-Histone H4 (1-25)-GSGSK(Biotin) - 1 mg

[Lys(Ac)12/16, Lys(Me3)20]-Histone H4 (1-25)-GSGSK(Biotin) - 1 mg

Item no.	AS-65226-1
Manufacturer	AnaSpec
Amount	1 mg
Category	Oncology Neuroscience Neural Epigenetics By Cell Type Carcinoma Peptides & Proteins Adenocarcinoma Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Purity	Peak Area by HPLC ≥95%
Sequence	H-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys(Ac)-Gly-Gly-Ala-Lys(Ac)-Arg-His-Arg-Lys(Me3)-Val-Leu-Arg-Asp-Asn-Gly-Ser-Gly-Ser-Lys(Biotin)-OH
Citations	Hemann, M. and M. Narita. Gene Dev 21, 1 (2007); Carmen, A. et al. J Biol Chem 277, 4778 (2002); Turner, B. et al. FEBS Lett 252, 141 (1989).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	SGRGKGGKGLG-K(Ac)-GGA-K(Ac)-RHR-K(Me3)-VLRDNGSGS-K(Biotin)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Catalog
Manufacturer - Category	Peptides
Manufacturer - Targets	Histone H4 Fragment; Histone
Shipping Temperature	RT
Storage Conditions	- 20 °C
Molecular Weight	3360
Description	This peptide is histone H4 (1-25) with acetylation at Lys12 and Lys16 and trimethylation at Lys20, followed by a C-terminal GSGS linker and a biotinylated Lys. Trimethylation at Lys20 of histone H4 is catalyzed by Suv4-20 and is involved in transcriptional silencing and heterochromatin formation in eukaryotes. It has been shown that histone H4 is preferentially acetylated first at Lys16, then at Lys12. Diacetylated histone H4 has been shown to bind repressor protein TUP1. Acetylation of histone H4 also regulates heterochromatin formation by promoting the binding of bromodomains to p300 and transcription factor TAFII250 and inhibiting interactions with SIR3. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Product Group	LB1A3Z
Research Area	Epigenetics / Lyophilized
Sequence One-Letter Code	SGRGKGGKGLG-K(Ac)-GGA-K(Ac)-RHR-K(Me3)-VLRDN-GSGSK(Biotin)
GTIN	5400535137182
Usage	Research use
UNSPSC	12352202

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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AS-65226-1-safety-datasheet.pdf