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Caspase 1 (ICE) Substrate 2, chromogenic

Caspase 1 (ICE) Substrate 2, chromogenic

Item no.	AS-25259-5
Manufacturer	AnaSpec
CASRN	149231-66-3
Amount	5 mg
Category	Neuroscience Neural Signaling Cell Biology Cell Status Apoptosis Reagents & Chemicals Staining & Dyes Fluorescent Reagents
Type	Fluorescent dyes and probes
Format	Lyophilized
Specific against	other
Purity	Peak Area by HPLC ≥95%
Sequence	Ac-Tyr-Val-Ala-Asp-pNA
Citations	Grutter MG (2000). Caspases: key players in programmed cell death. Curr Opin Struct Biol 10, 649-55; Gastman BR (2001). Apoptosis and its clinical impact. Head Neck 23, 409-25; Grutter MG (2000). Caspases: key players in programmed cell death. Curr Opin Struct Biol 10, 649-55; Stennicke HR and Salvesen GS (1999). Catalytic properties of the caspases. Cell Death Differ 6, 1054-9; Stennicke HR and Salvesen GS (1998). Properties of the caspases. Biochim Biophys Acta 1387, 17-31; Thornberry NA and Lazebnik Y (1998). Caspases: enemies within. Science 281, 1312-6; Talanian RV, et al. (1997). Substrate specificities of caspase family proteases. J Biol Chem 272, 9677-82; Fassy F, et al. (1998). Enzymatic activity of two caspases related to interleukin-1beta-converting enzyme. Eur J Biochem 253, 76-83; Datta R, et al. (1996). Activation of the CPP32 protease in apoptosis induced by 1-ß-D-arabinofuranosylcytosine and other DNA-damaging agents. Blood 88, 1936-43; Koeplinger KA, et al. (2000). Caspase 8: an efficient method for large-scale autoactivation of recombinant procaspase 8 by matrix adsorption and characterization of the active enzyme. Protein Expr Purif 18, 378-87.
ECLASS 10.1	30196090
ECLASS 11.0	30196090
UNSPSC	12000000
Alias	Ac-YVAD-pNA
Shipping Condition	Room temperature
Available
Manufacturer - Applications	Protease activity
Manufacturer - Category	Catalog Peptides / Catalog Peptides Gr / Peptides / Labeling & detection / non-fluorescent
Manufacturer - Targets	Caspase, Caspase 1
Manufacturer - Conjugate / Tag	Conjugates: PNA
Shipping Temperature	RT
Storage Conditions	- 20 °C Protected from light
Molecular Weight	628.7
Manufacturer - Research Area	Cancer & Apoptosis; Cell Signaling / Apoptosis & Cell Death; Enzyme Substrates & Inhibitors
Description	Caspase-1 substrate with Km = 23 µM and kcat = 1.5 M-1s-1; pNA (4-nitroaniline)-derived caspase substrates are widely used for the colorimetric detection of various caspase activities. Cleavage of pNA peptides by caspases generates pNA that is monitored colorimetrically at ~405 nm. pNA has maximum absorption around 408 nm.
Absorbtion (nm)	408
Sequence One-Letter Code	Ac-YVAD-pNA
Detection Method	Colorimetric
Post Synthesis Coupling	No
Usage	Research use
UNSPSC	12352202
GTIN	5400535038595

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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Delivery expected until 1/29/2026

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