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Caspase 3 (Apopain) Substrate 1r-z, fluorogenic

Caspase 3 (Apopain) Substrate 1r-z, fluorogenic

Item no.	AS-60304-5
Manufacturer	AnaSpec
CASRN	223538-61-2
Amount	5 mg
Category	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Cell Biology Cell Status Apoptosis Reagents & Chemicals Staining & Dyes Fluorescent Reagents
Type	Fluorescent dyes and probes
Format	Lyophilized
Specific against	other
Conjugate/Tag	Rhodamine
Purity	Peak Area by HPLC ≥95%
Sequence	z-(Asp-Glu-Val-Asp)2-Rh110
Citations	Gurtu V, et al. (1997). Fluorometric and colorimetric detection of caspase activity associated with apoptosis. Anal Biochem 251, 98-102; Martins LM, et al. (1997). Activation of multiple interleukin-1 ? converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis. J Biol Chem 272, 7421-30.
ECLASS 10.1	30196090
ECLASS 11.0	30196090
UNSPSC	12000000
Alias	(Z-DEVD)2-Rh110
Shipping Condition	Room temperature
Available
Manufacturer - Applications	FRET; Protease activity
Manufacturer - Category	Catalog Peptides / Catalog Peptides Gr / Peptides / Labeling & detection / Green (500 -550 nm)
Manufacturer - Targets	Caspase, Caspase 3
Manufacturer - Conjugate / Tag	Fluorescent dyes: Rhodamine110
Shipping Temperature	RT
Storage Conditions	- 20 °C Protected from light
Molecular Weight	1515.5
Manufacturer - Research Area	Cancer & Apoptosis; Cell Signaling / Apoptosis & Cell Death; Enzyme Substrates & Inhibitors
Description	Caspase-3 substrate and caspase-7 substrate; Rh110 (rhodamine 110)-derived caspase substrates are probably the most sensitive indicators widely used for the fluorimetric detection of various caspase activities. Cleavage of Rh110 peptides by caspases generates strongly fluorescent Rh110 that is monitored fluorimetrically at 510-530 nm with excitation of 488 nm, the most common excitation light source used in fluorescence instruments.
Absorbtion (nm)	488
Emission (nm)	520
Sequence One-Letter Code	(Z-DEVD)2-Rh110
Detection Method	Fluorescent
Feature	Fluorogenic substrates
Post Synthesis Coupling	No
Usage	Research use
UNSPSC	12352202
GTIN	5400535158538

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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AS-60304-5-safety-datasheet.pdf