Comparison

Anti-Nav1.1 Na+ Channel Antibody

Item no. 75-023-020
Manufacturer Antibodies Incorporated
Amount 20 uL
Category
Format Liquid
Applications WB, IP, IHC, ICC, ELISA
Clone K74/71
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Primate
Host Mouse
Isotype IgG1
Conjugate/Tag Unconjugated
Alias Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)
Shipping Condition Cool pack
Available
Manufacturer - Type
Primary Antibody
Manufacturer - Targets
Nav1.1 Na+ channel
Country of Origin
United States
Shipping Temperature
Shipped on ice packs
Storage Conditions
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Molecular Weight
220 kDa
Manufacturer - Research Area
Ion Channels and Modulators, Na+ Channels
Expiration
24 months from date of receipt
Immunogen
Fusion protein amino acids 1929-2009 (cytoplasmic C-terminus) of rat Nav1.1 (accession number P04774) produced recombinantly in E. Coli
Immunogen Species
Rat
Description
Our Anti-Nav1.1 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K74/71. It detects human, mouse, non-human primate, and rat Nav1.1 Na+ channel, and is purified by Protein A chromatography. It is great for use in ELISA, IHC, ICC, IP, WB.
Target Description
Nav1.1 Na+ channel (sodium channel, voltage-gated, type I, alpha subunit/ SCN1A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn1a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.1 Na+ channel is a sodium selective channel that maintains Na+ homeostasis by allowing Na+ ions to pass in accordance of their electrochemical gradient. The protein plays an important role in the release of neurotransmittors from the neurons. Therefore, Nav1.1 Na+ channel is involved in the perception of mechanical pain due to the activation of sematosensory neurons without the involvement of inflammation. Mutation of the gene encoding for Nav1.1 Na+ channel is one of the main cause of epilepsy and febrile seizures.
Clonality
Monoclonal
Manufacturer - Specificity
No cross-reactivity with Nav1.2, Nav1.3 and Nav1.6
Concentration
1 mg/mL
Form
Purified by Protein A chromatography
Buffer
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4
Production Notes
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
Quality Control
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
Quality Control: Application
WB Brain
Dilution Range: WB
1:500
Dilution Range: IHC
1:250
Dilution Range: ICC
1:250
Usage Statement
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Manufacturer - Statement
We produce our Nav1.1 Na+ channel mouse monoclonal primary antibody from hybridoma clone K74/71. It is great in ELISA, IHC, ICC, IP, WB and is purified by Protein A chromatography.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 20 uL
Available: In stock
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