ITGA4 / VLA-4 / CD49d Antibody (C-Terminus)

Human ITGA4 / Integrin Alpha 4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

ITGA4

H, M, Rb, Ha, Pr, Pig, D

Immunoaffinity purified

IHC-P (20 µg/ml)