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KEAP1 Antibody (C-Terminus)

KEAP1 Antibody (C-Terminus)

Item no.	ABC-ALS15665
Manufacturer	Abcepta
Amount	50 ug
Category	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Cell Biology Cell Movement Cell Adhesion Adenocarcinoma Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Type	Antibody Primary
Applications	WB, IF, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	Dhakshinamoorthy S.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. Nagase T.,et al.DNA Res. 2:167-174(1995). Ohara O.,et al.Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases. Ota T.,et al.Nat. Genet. 36:40-45(2004). Grimwood J.,et al.Nature 428:529-535(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Kelch-like ECH-associated protein 1,Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19,KEAP1,INRF2,KIAA0132,KLHL19
Similar products	KEAP1, INRF2, KIAA0132, KLHL19, Kelch-like ECH-associated protein 1, Cytosolic inhibitor of Nrf2, Kelch-like protein 19, INrf2
Available
Manufacturer - Targets	Human KEAP1. At least two isoforms of KEAP1 are known to exist.
Storage Conditions	Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
Bio Background	Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Clonality	Polyclonal
Gene Name	KEAP1 {ECO:0000303\|PubMed:14585973, ECO:0000312\|HGNC:HGNC:23177}
Subtitle	Rabbit Polyclonal Antibody
Reactivity	H
Calculated Molecular Weight	69666
Purification	Immunoaffinity purified
Concentration	1 mg/ml
Dilution	IHC-P (2.5 µg/ml), WB (1-2 µg/ml),
Antigen Type	Synthetic peptide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 1/1/2026

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