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Anti-4R-Tau pAb (Rabbit, Antiserum)

Anti-4R-Tau pAb (Rabbit, Antiserum)

Item no.	CAC-TIP-4RT-P01
Manufacturer	Cosmobio
Amount	50 ul
Category	Neuroscience Aging & Neurological Disorders Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Manufacturer - Applications	IHC(p), WB
Manufacturer - Category	Research Area/Cell Types/Glial Cells/Abs For Paraffin Embedded Tissue; Research Area/Disease/Parkinson Disease/Primary Antibodies; Antibodies/Abs For Paraffin Embedded Tissue/Neurodegeneration; Antibodies/Neurodegeneration/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Signal Transduction/Abs For Paraffin Embedded Tissue; Research Area/Disease/Parkinson Disease/Abs For Paraffin Embedded Tissue; Research Area/Neurobiology/Neurodegeneration/Abs For Paraffin Embedded Tissue; Antibodies/Neurodegeneration/Primary Antibodies; Antibodies/Primary Antibodies/Neurodegeneration; Research Area/Disease/Frontotemporal dementia/Abs For Paraffin Embedded Tissue; Research Area/Disease/Frontotemporal dementia/Primary Antibodies; Research Area/Disease/Pick disease of the brain/Abs For Paraffin Embedded Tissue; Research Area/Disease/Pick disease of the brain/Primary Antibodies; Research Area/Disease/Progressive supranuclear palsy/Abs For Paraffin Embedded Tissue; Research Area/Disease/Progressive supranuclear palsy/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Microtubules/Abs For Paraffin Embedded Tissue; Research Area/Organelles & Subcellular Structures/Microtubules/Primary Antibodies; Research Area/Cell Types/Astrocytes/Abs For Paraffin Embedded Tissue; Research Area/Cell Types/Astrocytes/Primary Antibodies; Research Area/Neurobiology/Axons/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Signal Transduction/Primary Antibodies; Research Area/Cell Types/Glial Cells/Primary Antibodies; Research Area/Cell Biology/Oxidative Stress/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Oxidative Stress/Primary Antibodies; Research Area/Development/Brain & CNS/Abs For Paraffin Embedded Tissue; Research Area/Development/Brain & CNS/Primary Antibodies; Research Area/Neurobiology/Memory & Learning/Abs For Paraffin Embedded Tissue; Research Area/Neurobiology/Memory & Learning/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Mitochondria/Abs For Paraffin Embedded Tissue; Research Area/Organelles & Subcellular Structures/Mitochondria/Primary Antibodies; Research Area/Cell Biology/Gene Expression & Transcription/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Gene Expression & Transcription/Primary Antibodies; Research Area/Cell Types/Neurons/Abs For Paraffin Embedded Tissue; Research Area/Cell Types/Neurons/Primary Antibodies; Research Area/Neurobiology/Axons/Primary Antibodies; Research Area/Cell Biology/Cytoskeleton/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Cytoskeleton/Primary Antibodies; Research Area/Neurobiology/Synapses/Abs For Paraffin Embedded Tissue; Research Area/Neurobiology/Synapses/Primary Antibodies; Research Area/Cell Biology/Autophagy/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Autophagy/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Chromosomes/Abs For Paraffin Embedded Tissue; Research Area/Organelles & Subcellular Structures/Chromosomes/Primary Antibodies; Research Area/Cell Biology/DNA Damage & Repair/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/DNA Damage & Repair/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Stress Granules/Abs For Paraffin Embedded Tissue; Research Area/Organelles & Subcellular Structures/Stress Granules/Primary Antibodies; Research Area/Neurobiology/Neurodegeneration/Primary Antibodies
Maker	CAC
Short Description	Anti-4R-Tau pAb — prepared from rabbits immunized with synthetic N279D 4R-tau peptide [VQIIDKKLDLSNVQSKC] — recognizes 4R tau isoforms, regardless of deamidation as occurs extensively in AD brains. \\Validated for western blot and IHC(p), this isoform-specific tau antibody is useful for immunohistochemical and biochemical studies of tau species in diverse neurodegenerative diseases.
Description	Anti-4R-Tau pAb — prepared from rabbits immunized with synthetic N279D 4R-tau peptide [VQIIDKKLDLSNVQSKC] — recognizes 4R tau isoforms, regardless of deamidation as occurs extensively in AD brains. Validated for western blot and IHC(p), this isoform-specific tau antibody is useful for immunohistochemical and biochemical studies of tau species in diverse neurodegenerative diseases. Tau is a microtubule-associated protein that assembles into insoluble, filamentous, and hyperphosphorylated inclusions in many neurodegenerative diseases. The adult human brain expresses 6 distinct splice forms divided into two groups depending on the inclusion of exon 10 to generate either 3-repeat (3R) or 4-repeat (4R) isoforms. Distinct tau isoforms accumulate in diseased brains: all 6 isoforms in AD, 3R tau in Pick’ s disease, and 4R tau in PSP and CBD. Therefore, isoform-specific tau antibodies are useful tools for immunohistochemical and biochemical studies of tau species in diseased brains. Tau deposited in AD is extensively deamidated at N279. This anti-4R tau pAb specifically recognizes 4R tau isoforms regardless of deamidation and strongly stained tau in AD brain. Specifications Product type primary antibody Immunogen synthetic N279D 4R-tau peptide (VQIIDKKLDLSNVQSKC) Raised in rabbit Source anti-serum Form liquid with 0.1% NaN3 as a preservative Volume 50 uL Label none Specificity unlabeled 4R-tau isoforms Cross reactivity human, mouse, rat Storage below -20° C. (below -70° C for prolonged storage). Aliquot to avoid cycles of freeze/thaw. Recommended dilutions Western blotting 1/2000-1/5000 Immunohistochemistry 1:3000-1/20000 Other applications have not been tested. Optimal dilutions/concentrations should be determined by the end user. References Hasegawa M, Watanabe S, Kondo H, et al, 3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease. Acta Neuropathol. 2013 Nov 9 Dan A, Takahashi M, Masuda-Suzukake M, et al.Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain. Acta Neuropathol
Purification	Serum
Clonality	Polyclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

CAC-TIP-4RT-P01.pdf

CAC-TIP-4RT-P01-datasheet.pdf

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Amount: 50 ul

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