Anti-SK2 potassium channel Antibody

Item no.	75-403
Manufacturer	Antibodies Incorporated
Amount	100 uL
Category	Neuroscience Neural Signaling Antibodies Immunohistochemistry Immunocytochemistry Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies Immunoblot
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IP, IHC, ICC
Clone	K78/29
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG1
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibody
Manufacturer - Targets	SK2 potassium channel
Country of Origin	United States
Shipping Temperature	Shipped on ice packs
Storage Conditions	Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Molecular Weight	50-80 kDa (and larger due to isoforms and dimerization/aggregation)
Manufacturer - Research Area	Ion Channels and Modulators, K+ Channels
Expiration	24 months from date of receipt
Immunogen	Synthetic peptide amino acids 546-562 (ENYDKHVTYNAERSRSS, cytoplasmic C-terminus) of rat SK2 (accession number P70604)
Immunogen Species	Rat
Description	Our Anti-SK2 potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K78/29. It detects human, mouse, and rat SK2 potassium channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Target Description	Potassium calcium-activated channel subfamily N member 2 is encoded by the gene KCNN2. KCNN2 is a member of the potassium KCNN family, KCa2.2/KCNN2 subfamily. KCNN2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Activation of KCNN2 leads to membrane hyperpolarization. KCNN2 is expressed in the brain. Diseases associated with KCNN2 include Dyskeratosis Congenita, Autosomal Dominant 3 and Coronary Aneurysm.
Clonality	Monoclonal
Manufacturer - Specificity	Does not cross-react with other SK channels
Concentration	1 mg/mL
Form	Purified by Protein A chromatography
Buffer	10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Production Notes	Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
Quality Control	Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.
Quality Control: Application	IHC
Usage Statement	These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Manufacturer - Statement	We produce our SK2 potassium channel mouse monoclonal primary antibody from hybridoma clone K78/29. It is great in IHC, ICC, WB and is purified by Protein A chromatography.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 uL

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Delivery expected until 9/11/2025

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