Anti-Nav1.2 Na+ Channel Antibody

Primary Antibody

United States

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Ion Channels and Modulators, Na+ Channels

Fusion protein amino acids 1882-2005 (cytoplasmic C-terminus) of rat rat Nav1.2 (accession number P04775) produced recombinantly in E. Coli

Nav1.2 Na+ channel (sodium channel, voltage-gated, type II, alpha subunit/ SCN2A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn2a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.1 Na+ channel is a sodium selective channel that maintains Na+ homeostasis by allowing Na+ ions to pass in accordance of their electrochemical gradient.Nav1.2 Na+ channel is implicated in the regulation of hippocampal replay, whose waves ripples (SPW-R) condition memories. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several cases of seizures, autism and bipolar disorders.

Lack of cross-reactivity against Nav1.1, Nav1.3, Nav1.6 verified

Purified by Protein A chromatography

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

WB Brain

1:250

2.5 µg

We produce our Nav1.2 Na+ channel mouse monoclonal primary antibody from hybridoma clone K69/3. It is great in IHC, ICC, IP, WB and is purified by Protein A chromatography.