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Anti-MESD Antibody

Anti-MESD Antibody

Item no.	75-129
Manufacturer	Antibodies Incorporated
Amount	100 uL
Category	Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies Immunohistochemistry Immunoprecipitation Primary Antibodies Immunoblot
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IP, IHC, ICC
Clone	N88/12
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG2b
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein)
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibody
Manufacturer - Targets	MESD
Country of Origin	United States
Shipping Temperature	Shipped on ice packs
Storage Conditions	Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Molecular Weight	26 kDa
Manufacturer - Research Area	Cell Signaling, Wnt Signaling
Expiration	24 months from date of receipt
Immunogen	Fusion protein amino acids 30-95 and 118-180 (lacking VSD domain) of mouse MESD (accession number Q9ERE7) produced recombinantly in E. Coli
Immunogen Species	Mouse
Description	Our Anti-MESD mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N88/12. It detects human, mouse, and rat MESD, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
Target Description	Mesoderm Development LRP Chaperone is encoded by the gene MESD. MESD is a member of the MESD family. MESD is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). MESD acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. MESD is essential for the specification of embryonic polarity and mesoderm induction. MESD plays an essential role neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. MESD is expressed in many tissues, but not in skeletal muscles. Diseases associated with MESD include Osteogenesis Imperfecta, Type Xx and Epilepsy, Nocturnal Frontal Lobe, 2.
Clonality	Monoclonal
Manufacturer - Specificity	No cross-reactivity reported
Concentration	1 mg/mL
Form	Purified by Protein A chromatography
Buffer	10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.56
Production Notes	Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
Quality Control	Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
Quality Control: Application	WB Brain
Usage Statement	These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Manufacturer - Statement	We produce our MESD mouse monoclonal primary antibody from hybridoma clone N88/12. It is great in IHC, ICC, IP, WB and is purified by Protein A chromatography.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 uL

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Delivery expected until 9/11/2025

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