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Anti-HCN4 Antibody

Anti-HCN4 Antibody

Item no.	75-150
Manufacturer	Antibodies Incorporated
Amount	100 uL
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry Immunocytochemistry Primary Antibodies Immunoblot
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IHC, ICC
Clone	N114/10
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Pig (Porcine, Sus scrofa domesticus)
Host	Mouse
Isotype	IgG1
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Shipping Condition	Cool pack
Available
Specificity	Gerbil, Human, Mouse, Pig, and Rat
Manufacturer - Type	Primary Antibody
Manufacturer - Targets	HCN4
Country of Origin	United States
Shipping Temperature	Shipped on ice packs
Storage Conditions	Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Molecular Weight	130 kDa
Manufacturer - Research Area	Ion Channels and Modulators, Other Ion Channels
Expiration	24 months from date of receipt
Immunogen	Fusion protein amino acids 1019-1108 (cytoplasmic C-terminus) of rat HCN4 (accession number Q9JKA7) produced recombinantly in E. Coli
Immunogen Species	Rat
Description	Our Anti-HCN4 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N114/10. It detects human, mouse, and rat HCN4, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Target Description	HCN4 is a member of the hyperpolarization-activated cyclic nucleotide gated channel family, also known as pacemaker channels. This family has a role in rhythmic activity of the heart and firing neurons. HCN channels are made up of four subunits, HCN1-4 and can be formed in multiple combinations. HCN4 is found in the cell membrane as a multi pass membrane protein in the sino-atrial node of the heart. This protein is highly expressed in neurons in the thalamus and other brain regions and testis. Mutations in HCN4 have been found in several types of sinus bradycardia.
Clonality	Monoclonal
Manufacturer - Specificity	No cross-reactivity against other HCN’s
Concentration	1 mg/mL
Form	Purified by Protein A chromatography
Buffer	10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.77
Production Notes	Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
Quality Control	Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
Quality Control: Application	WB Brain
Dilution Range: WB	1:500
Dilution Range: IHC	1:200
Dilution Range: ICC	1:200
Usage Statement	These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Manufacturer - Statement	We produce our HCN4 mouse monoclonal primary antibody from hybridoma clone N114/10. It is great in IHC, ICC, WB and is purified by Protein A chromatography.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 uL

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Delivery expected until 9/11/2025

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