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Anti-NALCN Antibody

Anti-NALCN Antibody

Item no.	75-220
Manufacturer	Antibodies Incorporated
Amount	100 uL
Category	Antibodies Immunocytochemistry Primary Antibodies Immunoblot
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, ICC
Clone	N185/7
Specific against	Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG1
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Sodium leak channel non-selective protein (Four domain-type voltage-gated ion channel alpha-1 subunit) (Rb21-channel) (Voltage gated channel-like protein 1)
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibody
Manufacturer - Targets	NALCN
Country of Origin	United States
Shipping Temperature	Shipped on ice packs
Storage Conditions	Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Molecular Weight	200 kDa
Manufacturer - Research Area	Ion Channels and Modulators, Other Ion Channels
Expiration	24 months from date of receipt
Immunogen	Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN (accession number Q6Q760) produced recombinantly in E. Coli
Immunogen Species	Rat
Description	Our Anti-NALCN mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N185/7. It detects mouse and rat NALCN, and is purified by Protein A chromatography. It is great for use in ICC, WB.
Target Description	Sodium Leak Channel, Non-Selective is encoded by the gene NALCN. NALCN is a member of the cation-nonselective channel family. NALCN is a voltage-independent, cation-nonselective channel which is permeable to sodium, potassium, and calcium ions. NALCN regulates the resting membrane potential and controls neuronal excitability. NALCN is expressed in the brain, heart, and pancreas. Diseases associated with NALCN include Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay and Hypotonia, Infantile, with Psychomotor Retardation and Characteristic Facies 1.
Clonality	Monoclonal
Manufacturer - Specificity	No cross-reactivity reported
Concentration	1 mg/mL
Form	Purified by Protein A chromatography
Buffer	10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Production Notes	Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
Quality Control	Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
Quality Control: Application	WB Brain
Usage Statement	These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Manufacturer - Statement	We produce our NALCN mouse monoclonal primary antibody from hybridoma clone N185/7. It is great in ICC, WB and is purified by Protein A chromatography.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 uL

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Delivery expected until 9/11/2025

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