Anti-MECP2 Antibody

MECP2

Shipped on ice packs

75 kDa

24 months from date of receipt

Human

MeCP2 (Methyl-CpG Binding Protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MeCP2 has been shown to mediate transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (Nan et al., 1998). Defects in MeCP2 are the cause of Rett syndrome (RTT) (Amir et al., 1999). RTT is an X-linked dominant disease; it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Reacts preferentially with dimethylated peptide than with unmethylated peptide

Purified by Protein A chromatography

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC

We produce our MECP2 mouse monoclonal primary antibody from hybridoma clone N227/21. It is great in DB, IHC and is purified by Protein A chromatography.