Anti-FKHR Antibody (3338) - 100 µg

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FKHR (ForKHead in Rhabdomyosarcoma), a 70kDa protein, is a member of the forkhead family of transcription factors. Members of this family are classified by their degree of homology in the 100-120aa region that is necessary for DNA binding and binding-site specificity. The FKHR subfamily differs from other members of the forkhead family in that all members contain an insertion of 5 amino acids next to the helix 3 in the middle of the forkhead domain and lack the conserved amino terminal KPPY sequence found in most forkhead genes. It has been shown that members of the FKHR gene family are phosphorylated by Akt which regulates its cellular localization promoting cell survival.

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