Anti-Transglutaminase-3 [C2D] - 100 µg

Antibody Products>Enzymes and Enzyme Inhibitor Antibodies|Primary Monoclonal Antibodies|Products

Next Day 2 - 8°C

Transglutaminase-3 (TG3), an epidermal- type enzyme, is responsible for formation of the epidermis. During keratinocyte differentiation, TG1 and TG3 appear to act cooperatively in the cross-linking of proteins, including involucrin, loricrin and small proline-rich proteins (SPRs). These reactions result in formation of the cornified envelope (CE), a specialized component consisting of covalent cross- links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Furthermore, TG3 in hair follicles is involved in cross-linking structural proteins such as trichohyalin and keratin intermediate to hardening the inner root sheath. During differentiation in these processes, a zymogen form of TG3 (77 kDa) is activated by limited proteolysis with cathepsins S and/or L.

Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose, 1mg/ml.