Anti-Epithelial Cell Adhesion Molecule (Ep-CAM) Antibody

Epithelial Cell Adhesion Molecule

Shipped on ice packs

40 kDa

24 months from date of receipt

Human

Epithelial specific antigen is a transmembrane glycoprotein (40 kDa) also known as ESA or epithelial cellular adhesion molecule (Ep-CAM). This protein is expressed on basolateral cell surface in most simple epithelia and vast majority of cancers. According to the “Cancer Stem Cells” (CSC) theory, tumors are not viewed as simple monoclonal expression of transformed cells, but rather as complex tissue where abnormal growth is driven by a minority pathological CSC pool that on one hand has acquired tumor related features such as uncontrolled growth and ability to form metasis and on the other hand maintains its inherent capacity to self renew and differentiate into a phenotypic ally heterogeneous, although aberrant progency. This antibody has been used recently to characterize the EpCAM high CD44+ versus EpCAM low/Cd44- indifferent cancer cells.

No cross-reactivity reported

Purified by Protein A Chromatography

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

WB

1:100

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.