Anti-IRF3 Mouse mAb

Uncategorized

Store at -20°C. Avoid freeze/thaw cycles.

Anti-IRF3 Mouse mAb

PBS, Glycerol, BSA

Recombinant Monoclonal

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages