Anti-alpha Smooth Muscle Actin Rabbit mAb

WB, IHC-P, ICC/IF, FC, IP

alpha Smooth Muscle Actin

Store at -20°C. Avoid freeze/thaw cycles.

Stable for 12 months from date of receipt/reconstitution.

Alpha smooth muscle actin encoded by the ACTA2 gene is a key protein in the highly conserved actin family, which plays a crucial role in cell motility, structure and integrity. This isoform is predominantly expressed in vascular smooth muscle cells, where it is essential for maintaining the structure and function of blood vessels and other smooth muscle tissues. Mutations in ACTA2 are linked to various vascular disorders, including familial thoracic aortic aneurysms and dissections (TAAD) and multisystemic smooth muscle dysfunction syndrome.

Anti-alpha Smooth Muscle Actin Rabbit mAb recognizes endogeneous level of alpha smooth muscle actin protein.

Unmodified

The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause a variety of myopathies, including nemaline myopathy, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects with manifestations such as hypotonia.